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ea0026p517 | Bone/calcium/Vitamin D | ECE2011

Genome-wide association in the Rotterdam study implicates the 16q24 locus as determinant of osteoporotic vertebral fractures

Oei H L D W , Estrada K , Castano-Betancourt M C , van der Klift M , Kerkhof J M , Hofman A , Pols H A P , Stolk L , van Meurs J B , Zillikens M C , Uitterlinden A G , Rivadeneira F

Risk for vertebral fractures (VFx), the most common osteoporotic fractures, is a heritable complex trait. No genome-wide association studies (GWAS) searching for genetic susceptibility factors for VFx have been reported. We performed a GWAS for VFx in a population-based study of Dutch elderly. Thoracolumbar spine radiographs were scored for osteoporotic VFx using the McCloskey/Kanis method. Genetic data was available in 329 VFx cases and 2666 controls. We tested 2 543 887 impu...

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Endocrine Abstracts

Genome-wide association in the Rotterdam study implicates the 16q24 locus as determinant of osteoporotic vertebral fractures

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